Article
Identification of major histocompatibility complex genotypes associated with resistance to an amphibian emerging infectious disease.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Sept 2023
Fu Minjie, Eimes John A, Kong Sungsik, Lamichhaney Sangeet, Waldman Bruce
Abstract excerpt
Amphibian chytridiomycosis, caused by Batrachochytrium dendrobatidis (Bd), emerged from Asia and spread globally. By comparing functional MHC IIß1 alleles from an Asian Bd-resistant anuran species (Bufo gargarizans) with those of an Australasian Bd-susceptible species (Litoria caerulea), we identified MHC genotypes associated with Bd resistance. These alleles encode a glycine deletion (G90β1) and adjacent motifs...
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