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Article

Structural basis of aspartylglucosaminuria.

Biochemical and biophysical research communications - 26 Dec 2008

Saito Seiji, Ohno Kazuki, Sugawara Kanako, Suzuki Toshihiro, Togawa Tadayasu, Sakuraba Hitoshi

Abstract excerpt

To elucidate the basis of aspartylglucosaminuria (AGU) from the viewpoint of enzyme structure, we constructed structural models of mutant aspartylglucosaminidase (AGA) proteins using molecular modeling software, TINKER. We classified the amino acid substitutions responsible for AGU and divided them into three groups based on the biochemical phenotype. Then, we examined the structural changes in the AGA protein...

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Source

Identifiers

PMID: 18992224
DOI: 10.1016/j.bbrc.2008.10.142

Genes

AGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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