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Article

NDRG1 deficiency attenuates fetal growth and the intrauterine response to hypoxic injury.

Endocrinology - 1 Mar 2014

Larkin Jacob, Chen Baosheng, Shi Xiao-Hua, Mishima Takuya, Kokame Koichi, Barak Yaacov, Sadovsky Yoel

Abstract excerpt

Intrauterine mammalian development depends on the preservation of placental function. The expression of the protein N-myc downstream-regulated gene 1 (NDRG1) is increased in placentas of human pregnancies affected by fetal growth restriction and in hypoxic primary human trophoblasts, where NDRG1 attenuates cell injury. We sought to assess the function of placental NDRG1 in vivo and tested the hypothesis that...

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Identifiers

PMID: 24424031
DOI: 10.1210/en.2013-1425
PMCID: PMC3929742

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