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Article

Concurrent high-grade glioma with cavernous malformations and pathogenic variants in PDCD10 and SMARCA4.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Nov 2023

Glanz Hannah, Damodharan Sudarshawn N, Smith-Simmer Kelcy, Helgager Jeffrey, Puccetti Diane

Abstract excerpt

The co-occurrence of multiple disease processes can pose diagnostic challenges. We report an unusual case of a patient found to have co-occurrences of an IDH1-mutant high-grade glioma along with cerebral cavernous malformations and pathogenic germline variants in PDCD10 and SMARCA4. Somatic testing was done on the tumor and identified a SMARCA4 and two TP53 variants. Within the literature, little is known about...

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PMID: 37328659
DOI: 10.1007/s00381-023-06026-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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