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Article

Association of Genetic Predisposition With Solitary Schwannoma or Meningioma in Children and Young Adults.

JAMA neurology - 1 Sept 2017

Pathmanaban Omar N, Sadler Katherine V, Kamaly-Asl Ian D, King Andrew T, Rutherford Scott A, Hammerbeck-Ward Charlotte, McCabe Martin G, Kilday John-Paul, Beetz Christian, Poplawski Nicola K, Evans D Gareth, Smith Miriam J

Abstract excerpt

Importance: Meningiomas and schwannomas are usually sporadic, isolated tumors occurring in adults older than 60 years and are rare in children and young adults. Multiple schwannomas and/or meningiomas are more frequently associated with a tumor suppressor syndrome and, accordingly, trigger genetic testing, whereas solitary tumors do not. Nevertheless, apparently sporadic tumors in young patients may herald a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28759666
DOI: 10.1001/jamaneurol.2017.1406
PMCID: PMC5710179

Genes

LZTR1
SMARCB1
SMARCE1
SUFU

Provenance

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