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Changes in Bone Density in Carriers of BRCA1 and BRCA2 Pathogenic Variants After Salpingo-Oophorectomy.

Obstetrics and gynecology - 1 Jul 2023

Chan Leslie N, Chen Lee-May, Goldman Mindy, Mak Julie S, Bauer Douglas C, Boscardin John, Schembri Michael, Bae-Jump Victoria, Friedman Sue, Jacoby Vanessa L

Abstract excerpt

OBJECTIVE: To evaluate the effect of risk-reducing salpingo-oophorectomy (RRSO) on change in bone mineral density (BMD) in women aged 34-50 years with pathogenic variants in BRCA1 or BRCA2 ( BRCA1 /2). METHODS: The PROSper (Prospective Research of Outcomes after Salpingo-oophorectomy) study is a prospective cohort of women aged 34-50 years with BRCA1 or two germline pathogenic variants that compares health...

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PMID: 37290104
DOI: 10.1097/AOG.0000000000005236

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