Article
Large scale proteomic studies create novel privacy considerations.
Scientific reports - 7 Jun 2023
Hill Andrew C, Guo Claire, Litkowski Elizabeth M, Manichaikul Ani W, Yu Bing, Konigsberg Iain R, Gorbet Betty A, Lange Leslie A, Pratte Katherine A, Kechris Katerina J, DeCamp Matthew, Coors Marilyn, Ortega Victor E, Rich Stephen S, Rotter Jerome I, Gerzsten Robert E, Clish Clary B, Curtis Jeffrey L, Hu Xiaowei, Obeidat Ma-En, Morris Melody, Loureiro Joseph, Ngo Debby, O'Neal Wanda K, Meyers Deborah A, Bleecker Eugene R, Hobbs Brian D, Cho Michael H, Banaei-Kashani Farnoush, Bowler Russell P
Abstract excerpt
Privacy protection is a core principle of genomic but not proteomic research. We identified independent single nucleotide polymorphism (SNP) quantitative trait loci (pQTL) from COPDGene and Jackson Heart Study (JHS), calculated continuous protein level genotype probabilities, and then applied a naïve Bayesian approach to link SomaScan 1.3K proteomes to genomes for 2812 independent subjects from COPDGene, JHS,...
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