Article
Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor.
Protein & cell - 7 Jun 2023
Wei Yinghui, Zhang Meiling, Hu Jing, Zhou Yingsi, Xue Mingxing, Yin Jianhang, Liu Yuanhua, Feng Hu, Zhou Ling, Li Zhifang, Wang Dongshuang, Zhang Zhiguo, Zhou Yin, Liu Hongbin, Yao Ning, Zuo Erwei, Hu Jiazhi, Du Yanzhi, Li Wen, Xu Chunlong, Yang Hui
Abstract excerpt
Approximately 140 million people worldwide are homozygous carriers of APOE4 (ε4), a strong genetic risk factor for late onset familial and sporadic Alzheimer's disease (AD), 91% of whom will develop AD at earlier age than heterozygous carriers and noncarriers. Susceptibility to AD could be reduced by targeted editing of APOE4, but a technical basis for controlling the off-target effects of base editors is...
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