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Article

Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.

Nature cancer - 1 Jun 2023

Adachi Yuta, Kimura Ryo, Hirade Kentaro, Yanase Shogo, Nishioka Yuki, Kasuga Natsumi, Yamaguchi Rui, Ebi Hiromichi

Abstract excerpt

Tumor cells evade targeted drugs by rewiring their genetic and epigenetic networks. Here, we identified that inhibition of MAPK signaling rapidly induces an epithelial-to-mesenchymal transition program by promoting re-localization of an apical-basal polarity protein, Scribble, in oncogene-addicted lung cancer models. Mis-localization of Scribble suppressed Hippo-YAP signaling, leading to YAP nuclear...

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PMID: 37277529
DOI: 10.1038/s43018-023-00575-2

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