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Article

Phase II, Open-Label Study of Encorafenib Plus Binimetinib in Patients With BRAFV600-Mutant Metastatic Non-Small-Cell Lung Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jul 2023

Riely Gregory J, Smit Egbert F, Ahn Myung-Ju, Felip Enriqueta, Ramalingam Suresh S, Tsao Anne, Johnson Melissa, Gelsomino Francesco, Esper Raymond, Nadal Ernest, Offin Michael, Provencio Mariano, Clarke Jeffrey, Hussain Maen, Otterson Gregory A, Dagogo-Jack Ibiayi, Goldman Jonathan W, Morgensztern Daniel, Alcasid Ann, Usari Tiziana, Wissel Paul, Wilner Keith, Pathan Nuzhat, Tonkovyd Svitlana, Johnson Bruce E

Abstract excerpt

PURPOSE: The combination of encorafenib (BRAF inhibitor) plus binimetinib (MEK inhibitor) has demonstrated clinical efficacy with an acceptable safety profile in patients with BRAFV600E/K-mutant metastatic melanoma. We evaluated the efficacy and safety of encorafenib plus binimetinib in patients with BRAFV600E-mutant metastatic non-small-cell lung cancer (NSCLC). METHODS: In this ongoing, open-label, single-arm,...

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Identifiers

PMID: 37270692
DOI: 10.1200/JCO.23.00774

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Phase II, Open-Label Study of Encorafenib Plus Binimetinib in Patients With BRAFV600-Mutant Metastatic Non-Small-Cell Lung Cancer.PMID 37270692Read ↗

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