Updated Efficacy and Safety From the Phase 2 PHAROS Study of Encorafenib Plus Binimetinib in Patients With BRAF V600E-Mutant Metastatic NSCLC-A Brief Report.

doi:10.1016/j.jtho.2025.05.023

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Article

Updated Efficacy and Safety From the Phase 2 PHAROS Study of Encorafenib Plus Binimetinib in Patients With BRAF V600E-Mutant Metastatic NSCLC-A Brief Report.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Oct 2025

Riely Gregory J, Ahn Myung-Ju, Clarke Jeffrey M, Dagogo-Jack Ibiayi, Esper Raymond, Felip Enriqueta, Gelsomino Francesco, Goldman Jonathan W, Hussein Maen, Johnson Melissa, Marrone Kristen A, Morgensztern Daniel, Nadal Ernest, Negrao Marcelo V, Offin Michael, Provencio Mariano, Ramalingam Suresh S, Roof Logan, Sanborn Rachel E, Smit Egbert F, Tsao Anne, Usari Tiziana, Alcasid Ann, Wilner Keith, Tonkovyd Svitlana, Zhang Xiaosong, Johnson Bruce E

Abstract excerpt

INTRODUCTION: The PHAROS primary analysis revealed robust antitumor activity and acceptable safety with encorafenib plus binimetinib in patients with BRAF V600E-mutant metastatic NSCLC (mNSCLC). We report results after 18 months of additional follow-up. METHODS: In this ongoing open-label, single-arm, phase 2 study, patients with BRAF V600E-mutant mNSCLC (59 treatment-naive and 39 previously treated) received...

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PMID: 40480428
DOI: 10.1016/j.jtho.2025.05.023
PMCID: PMC12451588

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