Updated Overall Survival Analysis From the Phase II PHAROS Study of Encorafenib Plus Binimetinib in Patients With BRAF V600E-Mutant Metastatic Non-Small Cell Lung Cancer.

doi:10.1200/JCO-25-02023

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Updated Overall Survival Analysis From the Phase II PHAROS Study of Encorafenib Plus Binimetinib in Patients With BRAF V600E-Mutant Metastatic Non-Small Cell Lung Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Dec 2025

Johnson Melissa L, Smit Egbert F, Felip Enriqueta, Ramalingam Suresh S, Ahn Myung-Ju, Tsao Anne, Johnson Bruce E, Offin Michael, Hussein Maen, Dagogo-Jack Ibiayi, Goldman Jonathan W, Clarke Jeffrey M, Negrao Marcelo V, Sanborn Rachel E, Morgensztern Daniel, Usari Tiziana, Wilner Keith, Alejandro Linh, Rifi Nada, Zhang Xiaosong, Riely Gregory J

Abstract excerpt

The phase II PHAROS study previously showed that encorafenib plus binimetinib has antitumor activity in patients with BRAF V600E-mutant metastatic non-small cell lung cancer (mNSCLC). In PHAROS, 98 patients (59 treatment-naïve; 39 previously treated) received encorafenib 450 mg once daily and binimetinib 45 mg twice daily. We report updated results from data cutoff of March 14, 2025. The median duration of...

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PMID: 41109959
DOI: 10.1200/JCO-25-02023
PMCID: PMC12680272

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