Article
NOTCH4ΔL12_16 sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1.
Nature communications - 2 Jun 2023
Zhang Bin, Dong Shaowei, Wang Jian, Huang Tuxiong, Zhao Pan, Xu Jing, Liu Dongcheng, Fu Li, Wang Lingwei, Wang Guangsuo, Zou Chang
Abstract excerpt
Resistance to epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI) remains one of the major challenges in lung adenocarcinoma (LUAD) therapy. Here, we find an increased frequency of the L12_16 amino acid deletion mutation in the signal peptide region of NOTCH4 (NOTCH4ΔL12_16) in EGFR-TKI-sensitive patients. Functionally, exogenous induction of NOTCH4ΔL12_16 in EGFR-TKI -resistant LUAD cells sensitizes...
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