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Article

Natural history of retinitis pigmentosa based on genotype, vitamin A/E supplementation, and an electroretinogram biomarker.

JCI insight - 8 Aug 2023

Comander Jason, Weigel DiFranco Carol, Sanderson Kit, Place Emily, Maher Matthew, Zampaglione Erin, Zhao Yan, Huckfeldt Rachel M, Bujakowska Kinga M, Pierce Eric

Abstract excerpt

BACKGROUNDA randomized clinical trial from 1984 to 1992 indicated that vitamin A supplementation had a beneficial effect on the progression of retinitis pigmentosa (RP), while vitamin E had an adverse effect.METHODSSequencing of banked DNA samples from that trial provided the opportunity to determine whether certain genotypes responded preferentially to vitamin supplementation.RESULTSThe genetic solution rate was...

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Identifiers

PMID: 37261916
DOI: 10.1172/jci.insight.167546
PMCID: PMC10445682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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