Article
"Paradoxical" p16 overexpression in cutaneous melanoma: Molecular and immunohistochemical analysis of a rare phenomenon with a focus on cell cycle regulatory molecules.
Pathology, research and practice - 1 Jul 2023
Ricci Costantino, Dika Emi, Corti Barbara, Lambertini Martina, Ambrosi Francesca, Cappilli Simone, Grillini Marco, Filippo Giorgia Di, Franchini Eugenia, Maloberti Thais, Fiorentino Michelangelo, Tallini Giovanni, Biase Dario de
Abstract excerpt
BACKGROUND: One of the most relevant genetic alterations in cutaneous melanoma (CM) is the biallelic inactivation/loss-of-heterozygosis (LOH) of cyclin-dependent kinase inhibitor 2 A (CDKN2A), which results in the immunohistochemical loss of p16 frequently found in CM. However, we recently described a rare case of dermal/deep-seated melanoma arising in giant congenital nevus (DDM-GCN) with p16 overexpression...
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