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Article

Investigating the shared genetic architecture of post-traumatic stress disorder and gastrointestinal tract disorders: a genome-wide cross-trait analysis.

Psychological medicine - 1 Dec 2023

Zhou Siquan, Luo Hang, Tian Ye, Li Haoqi, Zeng Yaxian, Wang Xiaoyu, Shan Shufang, Xiong Jingyuan, Cheng Guo

Abstract excerpt

BACKGROUND: Observational studies suggest a correlation between post-traumatic stress disorder (PTSD) and gastrointestinal tract (GIT) disorders. However, the genetic overlap, causal relationships, and underlining mechanisms between PTSD and GIT disorders were absent. METHODS: We obtained genome-wide association study statistics for PTSD (23 212 cases, 151 447 controls), peptic ulcer disease (PUD; 16 666 cases,...

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Genetic Associations and Epidemiology
Genome-Wide Association Study
Inflammatory Bowel Diseases
Irritable Bowel Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

Stress Disorders, Post-Traumatic

Stress Responses and Cortisol

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PMID: 37218628
DOI: 10.1017/S0033291723001423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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