Article
Reconstruction of the personal information from human genome reads in gut metagenome sequencing data.
Nature microbiology - 1 Jun 2023
Tomofuji Yoshihiko, Sonehara Kyuto, Kishikawa Toshihiro, Maeda Yuichi, Ogawa Kotaro, Kawabata Shuhei, Nii Takuro, Okuno Tatsusada, Oguro-Igashira Eri, Kinoshita Makoto, Takagaki Masatoshi, Yamamoto Kenichi, Kurakawa Takashi, Yagita-Sakamaki Mayu, Hosokawa Akiko, Motooka Daisuke, Matsumoto Yuki, Matsuoka Hidetoshi, Yoshimura Maiko, Ohshima Shiro, Nakamura Shota, Inohara Hidenori, Kishima Haruhiko, Mochizuki Hideki, Takeda Kiyoshi, Kumanogoh Atsushi, Okada Yukinori
Abstract excerpt
Human DNA present in faecal samples can result in a small number of human reads in gut shotgun metagenomic sequencing data. However, it is presently unclear how much personal information can be reconstructed from such reads, and this has not been quantitatively evaluated. Such a quantitative evaluation is necessary to clarify the ethical concerns related to data sharing and to enable efficient use of human...
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