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Article

Galanin ameliorates liver inflammation and fibrosis in mice by activating AMPK/ACC signaling and modifying macrophage inflammatory phenotype.

Frontiers in immunology - 1 Jan 2023

He Lingnan, Huang Chao, Wang Hui, Yang Naibin, Zhang Jianbin, Xu Leiming, Gu Ting, Li Zhenghong, Chen Yuanwen

Abstract excerpt

Background and aims: Galanin is a naturally occurring peptide that plays a critical role in regulating inflammation and energy metabolism, with expression in the liver. The exact involvement of galanin in non-alcoholic fatty liver disease and related fibrosis remains controversial. Methods: The effects of subcutaneously administered galanin were studied in mice with non-alcoholic steatohepatitis (NASH) induced by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37180164
DOI: 10.3389/fimmu.2023.1161676
PMCID: PMC10169601

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