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Article

The genetic predisposition and the interplay of host genetics and gut microbiome in Crohn disease.

Clinics in laboratory medicine - 1 Dec 2014

Jianzhong Hu

Abstract excerpt

Extensive genetic studies have identified more than 140 loci predisposing to Crohn disease (CD). Several major CD susceptibility genes have been shown to impair biological function with regard to immune response to recognizing and clearance of bacterial infection. Recent human microbiome studies suggest that the gut microbiome composition is differentiated in carriers of many risk variants of major CD...

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Identifiers

PMID: 25439275
DOI: 10.1016/j.cll.2014.08.003
PMCID: PMC4254428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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