Article
Morphometric analysis of nuclear shape irregularity as a novel predictor of programmed death-ligand 1 expression in lung squamous cell carcinoma.
Virchows Archiv : an international journal of pathology - 1 Apr 2024
Saito-Koyama Ryoko, Tamai Keiichi, Yasuda Jun, Okamura Yasunobu, Yamazaki Yuto, Inoue Chihiro, Miki Yasuhiro, Abe Jiro, Oishi Hisashi, Sato Ikuro, Sasano Hironobu
Abstract excerpt
Immune checkpoint inhibitor (ICI) therapy has been established as one of the key treatment strategies for lung squamous cell carcinoma (LUSQ). The status of programmed death-ligand 1 (PD-L1) in tumor cells and/or immune cells using immunohistochemistry has been primarily used as a surrogate marker for determining ICI treatment; however, when the tissues to be examined are small, false-negative results could be...
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