Article
Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci.
Schizophrenia bulletin - 29 Nov 2023
Jaholkowski Piotr, Hindley Guy F L, Shadrin Alexey A, Tesfaye Markos, Bahrami Shahram, Nerhus Mari, Rahman Zillur, O'Connell Kevin S, Holen Børge, Parker Nadine, Cheng Weiqiu, Lin Aihua, Rødevand Linn, Karadag Naz, Frei Oleksandr, Djurovic Srdjan, Dale Anders M, Smeland Olav B, Andreassen Ole A
Abstract excerpt
Low vitamin D (vitD) levels have been consistently reported in schizophrenia (SCZ) suggesting a role in the etiopathology. However, little is known about the role of underlying shared genetic mechanisms. We applied a conditional/conjunctional false discovery rate approach (FDR) on large, nonoverlapping genome-wide association studies for SCZ (N cases = 53 386, N controls = 77 258) and vitD serum concentration...
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