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Common mechanisms of physiological and pathological rupture events in biology: novel insights into mammalian ovulation and beyond

8 May 2023

Abstract excerpt

Ovulation is a cyclical biological rupture event fundamental to fertilisation and endocrine function. During this process, the somatic support cells that surround the germ cell undergo a remodelling process that culminates in breakdown of the follicle wall and release of a mature egg. Ovulation is driven by known proteolytic and inflammatory pathways as well as structural alterations to the follicle vasculature...

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PMID: 37157877
DOI: 10.1111/brv.12970

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