An Hspa8 variant is a shocking modifier of spinal muscular atrophy in mice.

Abstract excerpt

In this issue of Neuron, Kim et al.1 show that an Hspa8 variant modifies disease phenotypes in a mouse model of spinal muscular atrophy. Hspa8 facilitates the correct folding of proteins, enhances SNARE assembly, and influences SMN2 splicing.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Disease Models, Animal
• Share to Mice
• Share to Muscular Atrophy, Spinal