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ppBAM: ProteinPaint BAM track for read alignment visualization and variant genotyping.

Bioinformatics (Oxford, England) - 4 May 2023

Paul Robin, Wang Jian, Reilly Colleen, Sioson Edgar, Patel Jaimin, Matt Gavriel, Acić Aleksandar, Zhou Xin

Abstract excerpt

SUMMARY: ProteinPaint BAM track (ppBAM) is designed to assist variant review for cancer research and clinical genomics. With performant server-side computing and rendering, ppBAM supports on-the-fly variant genotyping of thousands of reads using Smith-Waterman alignment. To better visualize support for complex variants, reads are realigned against the mutated reference sequence using ClustalO. ppBAM also supports...

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PMID: 37140547
DOI: 10.1093/bioinformatics/btad300
PMCID: PMC10182850

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