Article
Reticuloendothelial activation and phenotypic alteration of peripheral monocytes with enhanced liver recruitment drive liver injury secondary to yellow phosphorus.
Journal of gastroenterology and hepatology - 1 Aug 2023
Vijayalekshmi Balakrishnan, Choudhary Anita, Alexander Vijay, Prabhu Savit B, Sharma Anand, Balasubramanian Kunissery A, Zachariah Uday, Eapen Chundamannil E, Goel Ashish
Abstract excerpt
BACKGROUND AND AIM: Monocytes and macrophages play a crucial role in the pathogenesis of acute liver failure (ALF). We aimed to study reticuloendothelial activation and its correlation with disease severity in commonly encountered yellow phosphorus (rodenticide)-induced hepatotoxicity patients. We also studied peripheral monocyte phenotype in a subset of patients. METHODS: Reticuloendothelial activation markers...
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