Article
Intraclonal diversity of the Pseudomonas aeruginosa cystic fibrosis airway isolates TBCF10839 and TBCF121838: distinct signatures of transcriptome, proteome, metabolome, adherence and pathogenicity despite an almost identical genome sequence.
Environmental microbiology - 1 Jan 2013
Klockgether Jens, Miethke Norbert, Kubesch Peter, Bohn Yu-Sing, Brockhausen Inka, Cramer Nina, Eberl Leo, Greipel Joachim, Herrmann Christian, Herrmann Susanne, Horatzek Sonja, Lingner Meike, Luciano Liliana, Salunkhe Prabhakar, Schomburg Dietmar, Wehsling Maria, Wiehlmann Lutz, Davenport Colin F, Tümmler Burkhard
Abstract excerpt
Microevolution of closely related Pseudomonas aeruginosa was compared in the clone TB strains TBCF10839 and TBCF121838 which had been isolated from two unrelated individuals with cystic fibrosis who had acquired clone TB during a local outbreak. Compared with the strain PAO1 reference sequence the two clone TB genomes shared 23 155 nucleotide exchanges, 32 out-of-frame indels in the coding region and another...
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