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Article

Establishing a Disease‐in‐a‐Dish Model to Study SARS‐CoV‐2 Infection During Prenatal Development

1 Apr 2023

Abstract excerpt

Mother-to-fetus transmission of the SARS-CoV-2 virus via the placenta has been reported but cannot readily be studied in pregnant women. This protocol describes an in vitro method to investigate SARS-CoV-2 infection of human embryonic stem cells (hESCs), which are similar to epiblast cells in young postimplantation embryos. First, SARS-CoV-2 viral pseudoparticles, which contain the spike protein and a fluorescent...

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PMID: 37098759
DOI: 10.1002/cpz1.759

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