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Article

ALS is imprinted in the chromatin accessibility of blood cells.

Cellular and molecular life sciences : CMLS - 24 Apr 2023

Kühlwein Julia K, Ruf Wolfgang P, Kandler Katharina, Witzel Simon, Lang Christina, Mulaw Medhanie A, Ekici Arif B, Weishaupt Jochen H, Ludolph Albert C, Grozdanov Veselin, Danzer Karin M

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a complex and incurable neurodegenerative disorder in which genetic and epigenetic factors contribute to the pathogenesis of all forms of ALS. The interplay of genetic predisposition and environmental footprints generates epigenetic signatures in the cells of affected tissues, which then alter transcriptional programs. Epigenetic modifications that arise from genetic...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37095391
DOI: 10.1007/s00018-023-04769-w
PMCID: PMC10126052

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