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Article

Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection.

Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2018

Zimmer Bastian, Ewaleifoh Osefame, Harschnitz Oliver, Lee Yoon-Seung, Peneau Camille, McAlpine Jessica L, Liu Becky, Tchieu Jason, Steinbeck Julius A, Lafaille Fabien, Volpi Stefano, Notarangelo Luigi D, Casanova Jean-Laurent, Zhang Shen-Ying, Smith Gregory A, Studer Lorenz

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) encephalitis (HSE) is the most common sporadic viral encephalitis in Western countries. Some HSE children carry inborn errors of the Toll-like receptor 3 (TLR3)-dependent IFN-α/β- and -λ-inducing pathway. Induced pluripotent stem cell (iPSC)-derived cortical neurons with TLR3 pathway mutations are highly susceptible to HSV-1, due to impairment of cell-intrinsic TLR3-IFN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30154162
DOI: 10.1073/pnas.1809853115
PMCID: PMC6140487

Genes

TLR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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