Article
Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population.
BMC medicine - 19 Apr 2023
Zhang Zhu, Li Haobo, Weng Haoyi, Zhou Geyu, Chen Hong, Yang Guoru, Zhang Ping, Zhang Xiangyan, Ji Yingqun, Ying Kejing, Liu Bo, Xu Qixia, Tang Yongjun, Zhu Guangfa, Liu Zhihong, Xia Shuyue, Yang Xiaohong, Dong Lixia, Zhu Ling, Zeng Mian, Yuan Yadong, Yang Yuanhua, Zhang Nuofu, Xu Xiaomao, Pang Wenyi, Zhang Meng, Zhang Yu, Zhen Kaiyuan, Wang Dingyi, Lei Jieping, Wu Sinan, Shu Shi, Zhang Yunxia, Zhang Shuai, Gao Qian, Huang Qiang, Deng Chao, Fu Xi, Chen Gang, Duan Wenxin, Wan Jun, Xie Wanmu, Zhang Peng, Wang Shengfeng, Yang Peiran, Zuo Xianbo, Zhai Zhenguo, Wang Chen
Abstract excerpt
BACKGROUND: A large proportion of pulmonary embolism (PE) heritability remains unexplained, particularly among the East Asian (EAS) population. Our study aims to expand the genetic architecture of PE and reveal more genetic determinants in Han Chinese. METHODS: We conducted the first genome-wide association study (GWAS) of PE in Han Chinese, then performed the GWAS meta-analysis based on the discovery and...
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