Correlated stabilizing selection shapes the topology of gene regulatory networks.

Abstract excerpt

The evolution of gene expression is constrained by the topology of gene regulatory networks, as co-expressed genes are likely to have their expressions affected together by mutations. Conversely, co-expression can also be an advantage when genes are under joint selection. Here, we assessed theoretically whether correlated selection (selection for a combination of traits) was able to affect the pattern of...

Topics

• Gene Regulatory Networks
• Models, Genetic
• Gene Expression Regulation
• Phenotype
• Mutation
• Selection, Genetic