Modeling of clinical phenotypes in systemic lupus erythematosus based on the platelet transcriptome and FCGR2a genotype.

doi:10.1186/s12967-023-04059-w

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Article

Modeling of clinical phenotypes in systemic lupus erythematosus based on the platelet transcriptome and FCGR2a genotype.

Journal of translational medicine - 7 Apr 2023

Cornwell MacIntosh G, Bannoudi Hanane El, Luttrell-Williams Elliot, Engel Alexis, Barrett Tessa J, Myndzar Khrystyna, Izmirly Peter, Belmont H Michael, Clancy Robert, Ruggles Kelly V, Buyon Jill P, Berger Jeffrey S

Abstract excerpt

BACKGROUND: The clinical heterogeneity of SLE with its complex pathogenesis remains challenging as we strive to provide optimal management. The contribution of platelets to endovascular homeostasis, inflammation and immune regulation highlights their potential importance in SLE. Prior work from our group showed that the Fcγ receptor type IIa (FcγRIIa)-R/H131 biallelic polymorphism is associated with increased...

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PMID: 37029410
DOI: 10.1186/s12967-023-04059-w
PMCID: PMC10082503

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