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Plasmodium falciparum gametocytes display global chromatin remodelling during sexual differentiation

3 Apr 2023

Abstract excerpt

BACKGROUND: The protozoan malaria parasite Plasmodium falciparum has a complex life cycle during which it needs to differentiate into multiple morphologically distinct life forms. A key process for transmission of the disease is the development of male and female gametocytes in the human blood, yet the mechanisms determining sexual dimorphism in these haploid, genetically identical sexual precursor cells remain...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 37013531
DOI: 10.1186/s12915-023-01568-4

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