Article
Neutral Models of De Novo Gene Emergence Suggest that Gene Evolution has a Preferred Trajectory.
Molecular biology and evolution - 4 Apr 2023
Iyengar Bharat Ravi, Bornberg-Bauer Erich
Abstract excerpt
New protein coding genes can emerge from genomic regions that previously did not contain any genes, via a process called de novo gene emergence. To synthesize a protein, DNA must be transcribed as well as translated. Both processes need certain DNA sequence features. Stable transcription requires promoters and a polyadenylation signal, while translation requires at least an open reading frame. We develop...
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