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Article

Early Resveratrol Treatment Mitigates Joint Degeneration and Dampens Pain in a Mouse Model of Pseudoachondroplasia (PSACH).

Biomolecules - 20 Oct 2023

Hecht Jacqueline T, Veerisetty Alka C, Patra Debabrata, Hossain Mohammad G, Chiu Frankie, Mobed Claire, Gannon Francis H, Posey Karen L

Abstract excerpt

Pseudoachondroplasia (PSACH), a severe dwarfing condition associated with early-onset joint degeneration and lifelong joint pain, is caused by mutations in cartilage oligomeric matrix protein (COMP). The mechanisms underlying the mutant-COMP pathology have been defined using the MT-COMP mouse model of PSACH that has the common D469del mutation. Mutant-COMP protein does not fold properly, and it is retained in the...

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Identifiers

PMID: 37892235
DOI: 10.3390/biom13101553
PMCID: PMC10605626

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Early Resveratrol Treatment Mitigates Joint Degeneration and Dampens Pain in a Mouse Model of Pseudoachondroplasia (PSACH).PMID 37892235Read ↗

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