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Article

Rare deleterious mutations in Bruton's tyrosine kinase as biomarkers for ibrutinib-based therapy: an in silico insight.

Journal of molecular modeling - 29 Mar 2023

Meena Jaishree, Hasija Yasha

Abstract excerpt

CONTEXT: Squamous cell carcinoma (SCC) is the second most common type of skin cancer caused by malignant keratinocytes. Multiple studies have shown that protein mutations have a significant impact on the development and progression of cancer, including SCC. We attempted to decode the effect of single amino acid mutations in the Bruton's tyrosine kinase (BTK) protein in this study. Molecular dynamic (MD)...

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PMID: 36991253
DOI: 10.1007/s00894-023-05515-6

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