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Generation of Parkinson's disease patient-derived human induced pluripotent stem cells line (PNUSCRi001-A) carrying a N227S mutation in GBA gene.

Stem cell research - 1 Dec 2022

Lee Nayeon, Moon Hye-Ji, Park So-Hyun, Moon Ji-Young, Park Ka-Kyung, Kim Jae-Ho, Lee Jae-Hyeok

Abstract excerpt

The hiPSC line was generated from peripheral blood mononuclear cells (PBMCs) collected by a male patient with young onset Parkinson's disease, carrying on heterozygous c.680 A > G (N227S) mutation in the GBA gene. The PBMCs was reprogrammed into an induced pluripotent stem cell (iPSC) line (PNUSCRi001-A hiPSCs) using non-integrative sendai virus. The hiPSC line, PNUSCRi001-A displayed a normal karyotype and the...

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PMID: 36332465
DOI: 10.1016/j.scr.2022.102959

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