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A gain‐of‐function mutation in microRNA 142 is sufficient to cause the development of T‐cell leukemia in mice

22 Mar 2023

Abstract excerpt

Abstract MicroRNAs (miRNAs) play a crucial role in regulating gene expression. MicroRNA expression levels fluctuate, and point mutations and methylation occur in cancer cells; however, to date, there have been no reports of carcinogenic point mutations in miRNAs. MicroRNA 142 (miR‐142) is frequently mutated in patients with follicular lymphoma, diffuse large B‐cell lymphoma, chronic lymphocytic leukemia (CLL),...

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PMID: 36945113
DOI: 10.1111/cas.15794

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