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DNA methylation abnormalities induced by advanced maternal age in villi prime a high-risk state for spontaneous abortion

21 Mar 2023

Abstract excerpt

BACKGROUND: Advanced maternal age (AMA) has increased in many high-income countries in recent decades. AMA is generally associated with a higher risk of various pregnancy complications, and the underlying molecular mechanisms are largely unknown. In the current study, we profiled the DNA methylome of 24 human chorionic villi samples (CVSs) from early pregnancies in AMA and young maternal age (YMA), 11 CVSs from...

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PMID: 36945044
DOI: 10.1186/s13148-023-01432-w

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