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Article

Acute pancreatitis risk in multifactorial chylomicronemia syndrome depends on the molecular cause of severe hypertriglyceridemia.

Atherosclerosis - 1 May 2024

Guay Simon-Pierre, Paquette Martine, Taschereau Amélie, Girard Lysanne, Desgagné Véronique, Bouchard Luigi, Bernard Sophie, Baass Alexis

Abstract excerpt

BACKGROUND AND AIMS: Multifactorial chylomicronemia syndrome (MCS) is a severe form of hypertriglyceridemia (hyperTG) associated with an increased risk of acute pancreatitis (AP). Severe hyperTG is mainly polygenic in nature, either caused by the presence of heterozygous pathogenic variants (PVs) in TG-related metabolism genes or by accumulation of common variants in hyperTG susceptibility genes. This study aims...

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PMID: 38448342
DOI: 10.1016/j.atherosclerosis.2024.117489

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