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Article

Maternal preconceptional inflammation transgenerationally alters metabolic and behavioral phenotypes in offspring.

Life sciences - 15 May 2023

Xin Yining, Sun Xiaoxiao, Ren Li, Chen Guo, Chen Yingqi, Ni Yingdong, He Bin

Abstract excerpt

AIMS: Evidence is accumulating that maternal inflammation induces phenotypic changes in the next generation. However, whether maternal preconceptional inflammation alters metabolic and behavioral phenotypes in offspring remains poorly understood. MAIN METHODS: Female mice were injected with either lipopolysaccharide or saline to establish the inflammatory model and then allowed to mate with normal males....

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PMID: 36933826
DOI: 10.1016/j.lfs.2023.121577

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