Article
Methyltransferase K-D-K-E motif influences the intercellular transmission of Newcastle disease virus.
Virulence - 1 Dec 2023
Li Xiao, Zhao Ye, Teng Qing-Yuan, Zhang Xue-Hui, Xue Jia, Zhang Guo-Zhong
Abstract excerpt
We previously demonstrated that two methyltransferase motifs, K-D-K-E and G-G-D, affect the pathogenicity of Newcastle disease virus (NDV) by regulating mRNA translation and virus transmission. Here, we compared the infectious centre area produced by the NDV strain, rSG10, and methyltransferase motifs mutant rSG10 strains in DF-1 cells. The results show that intercellular transmission was attenuated by...
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