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Article

Discrepancies between dihydropyrimidine dehydrogenase phenotyping and genotyping: What are the explanatory factors?

British journal of clinical pharmacology - 1 Aug 2023

Arrivé Capucine, Fonrose Xavier, Thomas Fabienne, Roth Gaël, Jacquet Emmanuelle, Brice Aurélie, Chirica Carole, Farneti Delphine, Frenoux Coralie, Stanke-Labesque Françoise, Gautier-Veyret Elodie

Abstract excerpt

AIM: Dihydropyrimidine dehydrogenase (DPD) deficiency can be detected by phenotyping (measurement of plasma uracil [U], with U ≥ 16 μg/L defining a partial deficiency) and/or by genotyping (screening for the four most frequent DPYD variants). We aimed to determine the proportion of discrepancies between phenotypic and genotypic approaches and to identify possible explanatory factors. METHODS: Data from patients...

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Identifiers

PMID: 36918744
DOI: 10.1111/bcp.15715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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