Article
DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7.
Clinical genetics - 1 Jul 2017
Di Nottia M, Masciullo M, Verrigni D, Petrillo S, Modoni A, Rizzo V, Di Giuda D, Rizza T, Niceta M, Torraco A, Bianchi M, Santoro M, Bentivoglio A R, Bertini E, Piemonte F, Carrozzo R, Silvestri G
Abstract excerpt
DJ-1 mutations are associated to early-onset Parkinson's disease and accounts for about 1-2% of the genetic forms. The protein is involved in many biological processes and its role in mitochondrial regulation is gaining great interest, even if its function in mitochondria is still unclear. We describe a 47-year-old woman affected by a multisystem disorder characterized by progressive, early-onset parkinsonism...
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