Article
Homeobox D9 drives the malignant phenotypes and enhances the Programmed death ligand-1 expression in non-small cell lung cancer cells via binding to Angiopoietin-2 promoter.
World journal of surgical oncology - 13 Mar 2023
He Jiabei, Jiang Mengjia, Liu Jing, Zhu Ruiping, Lv Weipeng, Lian Ruiqing, Yang Yang, Wang Ruoyu
Abstract excerpt
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Homeobox D9 (HOXD9), a member of the HOX family of transcription factors, plays a driver role in development of multiple cancers. Angiopoietin-2 (ANGPT2) is reportedly to facilitate angiogenesis, growth and metastasis in various cancers, including lung cancer. In addition, blocking ANGPT2 can effectively improve cancer...
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