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Tuning plant phenotypes by precise, graded downregulation of gene expression.

Nature biotechnology - 1 Dec 2023

Xue Chenxiao, Qiu Fengti, Wang Yuxiang, Li Boshu, Zhao Kevin Tianmeng, Chen Kunling, Gao Caixia

Abstract excerpt

The ability to control gene expression and generate quantitative phenotypic changes is essential for breeding new and desired traits into crops. Here we report an efficient, facile method for downregulating gene expression to predictable, desired levels by engineering upstream open reading frames (uORFs). We used base editing or prime editing to generate de novo uORFs or to extend existing uORFs by mutating their...

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PMID: 36894598
DOI: 10.1038/s41587-023-01707-w

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