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Article

Oral cancers preceded by proliferative verrucous leukoplakia exhibit distinctive molecular features

9 Mar 2023

Abstract excerpt

OBJECTIVE: Proliferative verrucous leukoplakia (PVL) has high rates of malignant transformation into oral squamous cell carcinoma (OSCC), but the clinical and evolutionary pattern of OSCC from PVL (PVL-OSCC) is more favorable than that of OSCC not preceded by PVL (OSCC). Here, we aimed to explore the pathophysiologic differences between PVL-OSCC and OSCC through transcriptomic and DNA methylation analyses....

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PMID: 36892444
DOI: 10.1111/odi.14550

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