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Article

Evaluating the Association Between Genetically Proxied Neurodevelopmental Language Phenotypes and the Risk of Primary Progressive Aphasia.

Neurology - 2 May 2023

Nassan Malik, Piras Ignazio S, Rogalski Emily, Geula Changiz, Mesulam M Marsel, Huentelman Matt

Abstract excerpt

BACKGROUND AND OBJECTIVES: Primary progressive aphasia (PPA) is a neurodegenerative syndrome of progressive language decline. PPA has 3 main subtypes: logopenic, semantic, and agrammatic. Observational studies suggested an association between language-related neurodevelopmental phenotypes and an increased risk of PPA. We sought to assess such relationships through Mendelian randomization (MR) approach, which can...

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Identifiers

PMID: 36889925
DOI: 10.1212/WNL.0000000000207136
PMCID: PMC10159766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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