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Article

Donor Microbiota Composition and Housing Affect Recapitulation of Obese Phenotypes in a Human Microbiota-Associated Murine Model.

Frontiers in cellular and infection microbiology - 1 Jan 2021

Kaiser Thomas, Nalluri Harika, Zhu Zhigang, Staley Christopher

Abstract excerpt

Human microbiota-associated (HMA) mouse models offer a valuable approach to study the role of intestinal microbiota in the development of obesity. In this study, we used an HMA model to evaluate whether engraftment of human obese or lean microbiota, from each of three donors, could recapitulate host phenotypes under conventional and specific-pathogen-free housing. Microbiota engraftment was correlated with donor...

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Identifiers

PMID: 33692965
DOI: 10.3389/fcimb.2021.614218
PMCID: PMC7937608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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