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Article

Metformin attenuates symptoms of osteoarthritis: role of genetic diversity of Bcl2 and CXCL16 in OA.

Arthritis research & therapy - 7 Mar 2023

Alimoradi Nahid, Tahami Mohammad, Firouzabadi Negar, Haem Elham, Ramezani Amin

Abstract excerpt

OBJECTIVE: This study aimed to evaluate the effectiveness of metformin versus placebo in overweight patients with knee osteoarthritis (OA). In addition, to assess the effects of inflammatory mediators and apoptotic proteins in the pathogenesis of OA, the genetic polymorphisms of two genes, one related to apoptosis (rs2279115 of Bcl-2) and the other related to inflammation (rs2277680 of CXCL-16), were...

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Identifiers

PMID: 36879307
DOI: 10.1186/s13075-023-03025-7
PMCID: PMC9990216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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